Autophagy: Cells SNARE Selves

Autophagy: Cells SNARE Selves

Autophagosomes sequester cytosolic constituents and deliver this cargo to lysosomes for destruction. Two groups now report that autophagosome maturation requires homotypic membrane fusion catalyzed by SNARE proteins.

Possible Selves

The concept of possible selves is introduced to complement current conceptions of self-knowledge. Possible selves represent individuals' ideas of what they might become, what they would like to become, and what they are afraid of becoming, and thus provide a conceptual link between cognition and motivation. Possible selves are the cognitive components of hopes, fears, goals, and threats, and th...

SNARE complex-mediated degranulation in mast cells

Mast cell function and dysregulation is important in the development and progression of allergic and autoimmune disease. Identifying novel proteins involved in mast cell function and disease progression is the first step in the design of new therapeutic strategies. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of proteins demonstrated to mediate th...

True Selves, False Selves, and the Ambiguity of Authenticity

Possible selves as roadmaps

Possible selves, expectations, and concerns about the coming year, can promote feeling good (‘‘I may not be doing well in school this year, but I will next year.’’) or can promote regulating for oneself (‘‘I may not be doing well in school this year, but to make sure I do better next year, I have signed up for summer tutoring.’’). We hypothesized that improved academic outcomes were likely only...